Continuous normothermic ex vivo perfusion improves kidney graft function
نویسندگان
چکیده
منابع مشابه
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Kidney transplantation has become a well-established treatment option for patients with end-stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the acceptance criteria for organ donors have been extended leading to the usage of marginal kidney grafts. These marginal organs tolerate cold storage poorly resulting in increased preservation injury and higher rat...
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BACKGROUND A significant proportion of kidneys procured for transplantation are discarded because of concerns about their suitability. In this study ex vivo normothermic perfusion (EVNP) was used as a quality assessment device before renal transplantation. METHODS Seventy-four human kidneys deemed unsuitable for transplantation following retrieval underwent 60 min of EVNP with an oxygenated r...
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MethodS: Two gluteal perforator flaps (matched control and intervention) were designed on sixteen 400g Sprague-Dawley male rats. NPWT was applied to the flap area directly continuously at -125mmHg for 7 days, after which the rats were divided into two principal groups. Group A (n=8) underwent 4D computed tomographic and angiography (CTA) with a body volume perfusion protocol after NPWT and euth...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2016
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2016.128